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Antibody boosts anti-lung cancer RT

By Liam Davenport
07 September 2007
Clin Cancer Res 2007; 13: 5211-5218

MedWire News: The anti-tumor effects of radiation therapy (RT) could be enhanced using the antiphosphatidylserine antibody 2aG4 to target phosphatidylserine on the luminal surface of tumor blood vessels, thereby making the vessels more vulnerable to cell-mediated cytotoxicity, indicate preliminary study results in mice.

The researchers conducted the study to find out whether RT could increase the exposure of phosphatidylserine on tumor vasculature and so enhance the effects of 2aG4.

Philip Thorpe, from the University of Texas Southwestern Medical Center at Dallas, USA, and colleagues studied the effects of RT plus 2aG4 on mice with radiation-resistant A549 human lung tumors. One group of mice was treated with RT plus 2aG4, while another received 2aG4 alone. A third group of untreated mice acted as controls.

Immunofluorescence staining was used to determine radiation-induced phosphatidylserine exposure on endothelial cells and A549 tumor cells, while histology and antibody-dependent cell-mediated cytotoxicity experiments revealed the mechanism behind improved tumor response.

Click here to see the rest of this article in MedWire News


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