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Stopping smoking long term reduces bronchial epithelial remodeling in COPD

By Caroline Price
30 November 2007
Respir Res 2007; 8: 85

MedWire News: Ex-smokers with chronic obstructive pulmonary disease (COPD) show less bronchial epithelial remodeling than current smokers with the lung disorder, study findings reveal.

The change in ex-smokers becomes more pronounced with increasing duration of smoking cessation, and significant 3.5 years after quitting.

COPD is associated with bronchial epithelial changes, including squamous cell metaplasia and goblet cell hyperplasia, which are partly attributed to activation of epithelial epidermal growth factor receptor (EGFR) expression.

Whereas smoking cessation is known to improve respiratory symptoms and slow lung function decline in COPD, so far no studies have looked at its potential to change epithelial features.

Endurance and resistance training maintain rehabilitation in COPD
By David Holmes
30 November 2007
Respir Med 2007; Advance online publication

MedWire News: Resistance training (RT) and endurance training (ET) both sustain and improve the effects of in-patient pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD), with little difference detected between the two training methods, a Norwegian study shows.

"The choice between RT or ET, or a combination, may be guided by individual needs, patient preferences and the availability of equipment," the authors write in the journal Respiratory Medicine.

Pulmonary rehabilitation (PR) improves impairment and disability in patients with COPD. Physical training is a key aspect of PT, and is capable of generating significant improvements in health-related quality of life (HRQOL) on its own, the authors report. However, these benefits fade over time in the absence of physical activity.


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